5 Reagents for medical use, namely, molecular and cellular biology reagents and assays for the modification of cells and DNA; pharmaceutical preparations and therapeutic agents, namely, for gene therapy and DNA editing; pharmaceutical and biological preparations for medical use for the treatment of genetic and genomic disorders by gene, genome, and cellular editing, modulation, and modification for use in human and animal therapeutics; pharmaceutical preparations, namely, therapeutic pharmaceuticals developed through genome modifications for the prevention and treatment of genomic disorders in humans and animals