5 Enzymes, nucleic acid molecules, and compounds/agents for modifying small RNAs with targeting agents for medical use, namely, use of the modified small RNAs in the gene editing industry; pharmaceutical preparations and therapeutic agents, namely, for gene therapy and mRNA regulation; pharmaceutical and biological preparations for medical use for the treatment of genetic and genomic disorders by gene therapy and mRNA regulation for use in human and animal therapeutics; pharmaceutical preparations, namely, therapeutic pharmaceuticals developed through genome modifications for the prevention and treatment of genomic disorders in humans and animals; pharmaceutical preparations for gene therapy and mRNA regulation