10 Skin substitute grafts; synthetic tissue grafts used in medical and surgical procedures and applications; medical biomaterials made of bioactive glass, including borate based bioactive glass; antimicrobial products, namely, synthetic tissue grafts for the prevention and treatment of microbial diseases or symptomatic infections in humans; medical devices and apparatuses, namely, surgical implants or microfiber based matrixes made of engineered synthetic biomaterials, including specifically bioactive glass, for use in wound management, fluid absorption, and the repair, reinforcement, support and ingrowth of tissue