5 Biopharmaceutical active substances, namely, pharmaceutical preparations and substances for the treatment of oncological-related diseases and disorders; Biological preparations for the treatment of cancer; therapeutic proteins for use in the manufacture of pharmaceutical preparations; Engineered fusion proteins for medical diagnostic and treatment purposes, namely, fusion proteins created through the use of circular permutation technology, engineered interleukins for optimizing patients' immune cellular response to prevent cancer-associated morbidity and mortality and tumor-targeted immunotherapeutic fusion proteins; Cytokine and protein based treatments for oncology-related diseases and disorders; Cytokine and protein fusions medicines having enhanced pharmacokinetics for cancer immunotherapy research and development