5 Pharmaceutical preparations for humans and animals for the prevention and treatment of neurologic, cardiovascular, dermatologic, inflammatory, immunologic, neuromuscular, reproductive, pancreatic, metabolic, hepatic, inflammatory, psychiatric, and orthopedic diseases, disorders, and conditions; Pharmaceutical preparations for humans and animals for the prevention and treatment of substance use disorder and substance withdrawal; Pharmaceutical preparations for humans and animals for use in treating and managing diseases, disorders, and conditions relating to aging; Therapeutic preparations for humans and animals, namely, therapeutic pharmaceutical preparations for the treatment and prevention of intracellular NAD depletion; Therapeutic preparations for humans and animals, namely, therapeutic pharmaceutical preparations for replenishing coenzyme depletion; Therapeutic agents for humans and animals for regulation of gene expression in aging and metabolic disease, nutrient sensing, and inflammasome suppression