5 Medical, biological, and pharmaceutical preparations for treating cancers, auto-immune diseases, cardio metabolic diseases, infectious diseases, inflammatory diseases, and metabolic diseases; RNA-based therapeutics and therapeutic agents for in vivo, ex vivo, or in situ treatment of cancers, auto-immune diseases, cardio metabolic diseases, infectious diseases, inflammatory diseases, and metabolic diseases; medical, biological and pharmaceutical preparations containing lipid nanoparticles for the prevention and treatment of cancers, auto-immune diseases, cardio metabolic diseases, infectious diseases, inflammatory diseases, and metabolic diseases; RNA-based therapeutics and therapeutic agents for in vitro preparation and in vivo, ex vivo, or on vivo delivery to cell sites; nucleic acid sequences and chemical reagents for medical and veterinary purposes