5 A pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals, namely, for treatment of AIDS, infectious diseases; a pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on humans, namely, for AIDS, infectious diseases, a pharmaceutical composition featuring a pharmaceutical carrier and an isotope selective ingredient having at least one of a chemical element and a chemical compound containing the chemical element whereby isotope distribution in the at least one of the chemical element and the chemical compound containing the chemical element is different from natural distribution of at least one of isotopes wherein the part of selected isotope of the chemical element ranges from 0 to 100 %, wherein the selected isotopes include stable isotopes having at least one of K-39, Mg -24, Zn-64, Rb-85, Si-26 and combination thereof and all other isotopes, wherein the pharmaceutical carrier is in the form of a solution, a gel, a cream, a spray, an aerosol, a patch, nanoparticles, inorganic molecules, organic molecules, a plant, a fruit and a vegetable, the pharmaceutical composition for treating AIDS, infectious diseases