5 Antigen-binding polypeptides for prevention and treatment of infectious diseases, immune and inflammatory diseases, malignancies and cancers, metabolic diseases, cardiovascular diseases, diseases of the central nervous system, neurogenerative diseases; immunoglobulin moieties, fragments or derivatives thereof for prevention and treatment of infectious diseases, immune and inflammatory diseases, malignancies and cancers, metabolic diseases, cardiovascular diseases, diseases of the central nervous system, neurogenerative diseases